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The ball mill is, of course, a sealed vessel, and the authors show that the lowerboiling additives seem to be more effective, presumably because they increase the internal pressure. And it's not like there's no catalyst present, because you have the stainless steel.
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A ball mill is a type of grinder or mill used to mill the materials into fine powder in pharmaceutical industry. Read About History, Description, Parts,Construction, Ball Mill Working, Principle, Ball Mill Types, and Applications
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ICH Official web site : ICH. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the United States and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration.
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A pharmaceutical ball mill is usually a cylindrical crushing device that is used for grinding of pharmaceutical powders by rotation around a horizontal axis. Size reduction_Pharmaceutical engineering SlideShare.
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